Featured Image
Photo by Joel Filipe on Unsplash
Why is it important?
The mechanism involved in the effects of repeated exposures of Particulate Matter in the lung injury induce extracellular matrix remodeling of airway and alveolar walls, which could contribute to the pulmonary mechanical changes. The mechanism involved is, at least, dependent on the inducible nitric oxide activation. The clinical relevance is related to two important views: First, we developed an experimental model to study air pollution with repeated instillations that can be used to investigate physiopathological mechanisms. Second, we clearly showed that iNOS is involved in lung inflammation induced by particulate matter. Further studies involved other mechanics such as the role of oxidative stress, IL-17 and cholinergic anti-inflammatory system, as recent studies suggested.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to air pollution groups contacting us and ultimately to a greater involvement in experimental model to study air pollution and physiopathological mechanisms research.
Edna Leick
Faculdade de Medicina da Universidade de São Paulo
Read the Original
This page is a summary of: iNOS Inhibition Reduces Lung Mechanical Alterations and Remodeling Induced by Particulate Matter in Mice, Pulmonary Medicine, March 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/4781528.
You can read the full text:
Contributors
The following have contributed to this page
