Alleviation of Drugs and Chemicals Toxicity: Biomedical Value of Antioxidants

What is it about?

Understanding the mechanism of drug- and chemical-induced toxicities is the primary interest of many researchers worldwide to develop enhanced preventive and therapeutic strategies. Paracelsus (the father of toxicology) assumed that all chemicals and drugs as well as natural products—including antioxidants—could induce toxicity when received in high doses. His rule “the dose makes the poison” is now considered the core principle of traditional toxicology. Recently, researchers understood that toxicity is a complicated process affected by many factors, including developmental exposures, genetic predisposition, and doses .

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Why is it important?

Antioxidants exist naturally in many beverages, fruits, and vegetables, and they can be synthesized in laboratories. They delay or ameliorate cellular oxidative damage; therefore, they have several health benefits in the prevention and treatment of diseases. They could be used alone or in combination with other medications as adjuvant treatments.