Describing the differences and clinical impact of the different classes of antihypertensives

What is it about?

This paper describes the following classes of antihypertensives: thiazide diuretics, renin angiotensin aldosterone system inhibitors, beta blockers, and calcium channel blockers. It starts off by describing the level of evidence needed to determine between class and within class differences and then reviews each class of antihypertensive and the evidence within each class that there are similarities or differences in action and outcomes.

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Why is it important?

This manuscript helps clinicians understand how these classes of antihypertensives work, how to prescribe them, and summarizes the evidenciary base for the strong clinical practice guidelines on the use of these antihypertensives to manage hypertension.