What is it about?
This new estimation model is our contribution to overcoming the limitations of existing methods, in contrast to the existing estimation method. In this paper, we model the overall EVs uptake by a second order chemical reaction based on rates of binding, recycling, internalization and half life of EVs. It is expressed in terms of ordinary differential equations (ODEs), whose coefficients are estimated through a complex fitting function that we derive in the frequency domain.
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Why is it important?
The benefit of using EVs for targeted drug delivery is to fight naturally cancer by NK cells, or to inject a drug into an "artificial EV" called liposome to protect it from enzymes into the environment or to allow the passage through the blood-brain-barrier. For studying and using this application you need to know the rates and/or the reaction involved into the EVs uptake at the target cell.
Perspectives
Important applications for the reaction rate estimation may be modeling molecular communication channel, studying the cellular mechanism, finding new drug delivery strategies and new technologies applications. In future works we will compare numerical results with experimental data, with the aim to study the parameters impact on the vesicular uptake.
Fabrizio Pappalardo
Universita degli Studi di Catania
Read the Original
This page is a summary of: Reaction rates estimation for the endocytic reception in extracellular vesicles-mediated communications, October 2022, ACM (Association for Computing Machinery),
DOI: 10.1145/3558583.3558848.
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