What is it about?

Protein Function is conserved in Protein domains. These are able to perform independent folding and are approximately conserved among species. A major goal in the study of proteins is the identification and characterization of domains and domain families. We have used methods of entropy calculation to that end.

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Why is it important?

Some algorithms have appeared in the scientific literature to obtain information on domains from three-dimensional structure of proteins, but many of these results do not agree with those defined by expert biologists.

Perspectives

A time statistical analysis of aminoacid sequences should then be performed in order to improve the classification.

Nicolas Carels
Oswaldo Cruz Foundation

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This page is a summary of: ENTROPY MEASURES BASED METHOD FOR THE CLASSIFICATION OF PROTEIN DOMAINS INTO FAMILIES AND CLANS, April 2014, World Scientific Pub Co Pte Lt,
DOI: 10.1142/9789814602228_0012.
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