Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway

What is it about?

Hypothalamic inflammation and increased oxidative stress are believed to be contributory mechanisms underlying obesity. Tempol, a free radical scavenger, has been shown to reduce inflammation and oxidative stress. We hypothesized that brain infusion of tempol would reduce oxidative stress and thus reduce food intake and body weight and improve body composition in aged-related obese rats with known elevated oxidative stress. Further, we predicted an associated increase in markers of leptin signalling, including the SIRT1/ AMPK and STAT3 pathways. For this purpose, mini osmotic pumps were placed in the intracerebroventricular region for the continuous infusion of tempol or vehicle for two weeks in young (3 months) and aged (23 months) male F344xBN rats.

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