What is it about?
The main aim of this study was to determine the maximum tolerated dose of estradiol, progesterone, and the mixture of both to restore normal sleep in a model of menopause in rats. The second purpose was to describe the in vitro activity of glutamate decarboxylase in sleep-related brain areas in the presence or absence of sex hormones.
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Why is it important?
No data in the literature have evaluated sex hormone dose escalation for treating abnormal sleep of ovariectomized rats nor tudies on the role of sex hormones in GABA synthesis of rats’ sleep-related areas.
Perspectives
The maximum tolerated dose coincided with the full dose of estradiol (17β-E2) and progesterone (P) used. Furthermore, the estrogen and progesterone combination treatments restored normal sleep in the menopause model compared to the SHAMs without toxic effects. The in vitro model demonstrated that 17β-E2 plus P presence in the assay increased the activity of GAD65 in the studied brain tissues. These results could be potentially important in laying the groundwork for developing a clinically applicable 17β-E2 plus P to improve the sleep of perimenopausal women with this problem. Therefore, it is necessary to carry out more studies to strengthen this line of research.
Dr Marisa Cabeza
Universidad Autónoma Metropolitana-Xochimilco
Read the Original
This page is a summary of: Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas, Canadian Journal of Physiology and Pharmacology, October 2023, Canadian Science Publishing,
DOI: 10.1139/cjpp-2022-0524.
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