What is it about?
By employing a metallomics method we show that the addition of glutathione to blood plasma either before or after cisplatin changes its metabolism. The detection of a new platinum-sulfur complex in plasma implies that its formation is directly involved in the process by which glutathione protects mammals from the cisplatin-induced toxicity.
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Why is it important?
These finding are important because they identify another small molecular sulfur compound that can be employed to modulate the metabolism of cisplatin in a desireable way to reduce the toxic side effects of cisplatin.
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This page is a summary of: Modulation of the metabolism of cis -platin in blood plasma by glutathione , Canadian Journal of Chemistry, April 2016, Canadian Science Publishing,
DOI: 10.1139/cjc-2015-0395.
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