Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet

What is it about?

Hypolipidemic and hypoglycemic properties of ginger in animal models have been reported. However, information related to the mechanisms and factors involved in the metabolic effects of ginger at a hepatic level are limited. The hypolipidemic and insulin sensitizing effects of ginger in HFD rats rely, at least in part, on enhanced liver expressions of PPARα, PPARγ and GLUT-2, and on a reduction of GPAT and SREBP1c. These effects were accompanied by a reduction of plasma leptin and an enhancement of plasma adiponectin levels.

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