Response to BotulinumtoxinA in a migraine cohort with multiple comorbidities and widespread pain

What is it about?

The PREEMPT protocol for Botox injection to combat chronic migraine has been shown to work in clinical trials that led to its FDA approval. We have evaluated how well it works and in which in a large group of high risk pain patients with multiple commodities in addition to chronic migraine. It worked in about half the patients, had decreased effect over time and was less likely to work in the young and / or depressed patient.

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