Aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in immune-mediated optic neuritis at long-term follow-up

What is it about?

Autoimmune optic neuropathies is an expanding field. This study describes how a well described clinical phenotype evolved over more than a decade into distinct auto-antibody specific subgroups. The clinical phenotype was originally described as Chronic Relasping Inflammatory Optic Neuropathy (CRION). Since the discovery of AQP4-IgG and MOG-IgG about 50% of patients of the original CRION cohort can be characterised as NMO-ON and MOG-ON. The recognition of these forms of autoimmune ON is relevant for patient management consequences which are different to what is contemporary practise for Multiple Sclerosis associated ON (MSON).

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