Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility

What is it about?

Serrated polyposis syndrome is a clinical entity characterized by multiple serrated polyps throughout the colon and increased risk for colorectal cancer. The basis for its genetic predisposition is largely unknown.

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Why is it important?

Some genetic variants for colorectal cancer risk are also involved in serrated polyposis syndrome susceptibility, implying that part of the risk for this neoplasm is mediated through these precursor lesions.