Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease

What is it about?

Variability in genetics can result in variability in how a disease progresses and presents in patients. We show that this variability may be contributing to the high failure rate of clinical trials for neurodegenerative diseases. Using patients’ genetic information, we can assign patients to treatment and control groups in a way that balances genetic differences. Through this, we can minimize disease variance and design more robust clinical trials.

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