What is it about?
We found that abnormally high neutrophil counts occur in about 1/3 of patients with uterine carcinosarcoma, an aggressive form of uterine cancer. Furthermore, we found that the blood neutrophil count is an independent poor prognostic factor in patients with uterine carcinosarcoma.
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Why is it important?
Our findings show that circulating neutrophils are linked to the aggressive phenotype and poor survival of patients with uterine carcinosarcoma.
Perspectives
Complete blood counts are routinely measured in women with uterine cancer. Thus, blood levels of neutrophils are readily available in women with uterine cancer, and may provide useful prognostic information. Whether or not circulating neutrophils correlate with alterations in the tumor microenvironment and/or directly influence uterine cancer progression is unknown and merits further investigation.
Gloria Huang
Yale University
Read the Original
This page is a summary of: Neutrophilia and mortality in women with uterine carcinosarcoma, International Journal of Gynecological Cancer, July 2019, BMJ,
DOI: 10.1136/ijgc-2019-000440.
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