Overexpression of SLC12A5 is associated with tumor progression and poor survival in ovarian carcinoma

What is it about?

Ovarian cancer is a major cause of death among all gynecological malignancies. To date, the identification of the prevalence and clinical/prognostic significance of genetic markers in this cancer is still limited. Recently, it has been identified that SLC12A5 plays a putative oncogenic role in cancers. However, the status of SLC12A5 expression in ovarian cancer and its potential clinical/prognostic significance are still obscure. In this paper, the expression dynamics of SLC12A5 in a series of human ovarian tissue, normal and pathological, non-neoplastic and neoplastic, were examined. We provide evidence, for the first time, that the high expression of SLC12A5 might participate in the acquisition of an aggressive phenotype and serve as an independent prognostic molecular marker in ovarian carcinomas. We think this manuscript is timely and the data should be helpful to the scientific community, particularly to those individuals interested in the clinical/prognostic significance of genetic biomarkers in human cancers including ovarian cancer.

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