What is it about?
It has been shown that changes which affect the loading conditions on the heart affect left ventricular trabeculation extent, such as during pregnancy and during extreme athletic-level physical activity. Excessive levels of this trabeculation are seen in a condition termed left ventricular non-compaction (LVNC) cardiomyopathy. Our study aims to assess whether this relationship occurs at non-extreme levels of physical activity.
Featured Image
Why is it important?
This is the first study to assess this relationship within a community-based population (with a physical activity distribution more representative of a general population) using cardiovascular magnetic resonance (CMR) imaging. The UK Biobank study provided our sample cohort.
Perspectives
As our findings demonstrated no evidence to suggest that any relationship occurred at non-athletic levels of physical activity, this implied that increased trabeculation extent does not occur as an epiphenomenon to other measures of exercise-induced cardiac remodelling seen in these circumstances, and also led us to postulate whether a threshold of higher physical activity level exists beyond which exercise-related changes in trabeculation extent occur.
Simon Woodbridge
Queen Mary, University of London
Trabeculations in the left heart have been much debated - what is the relevance for diagnosis of non-compaction and prognosis? Here we provide evidence that- contrary to some recent evidence - trabeculations are not related to physical activity - at least not in a population sample.
Professor Steffen E Petersen
Queen Mary University of London
Read the Original
This page is a summary of: Physical activity and left ventricular trabeculation in the UK Biobank community-based cohort study, Heart, February 2019, BMJ,
DOI: 10.1136/heartjnl-2018-314155.
You can read the full text:
Contributors
The following have contributed to this page
