Nucleos(t)ide analogues in patients with chronic hepatitis B: to stop or not to stop?

What is it about?

compared to long-term NA therapy, a finite approach of NA treatment with a satisfactory rate of functional cure is possible in highly selected population of non-cirrhotic HBeAg-negative patients who can have a close follow-up. However, further studies are needed to define potential predictors and re-treatment criteria to maximize the benefits of HBsAg loss and minimize the adverse outcomes of severe hepatitis flare after stopping NA therapy.

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