Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity

What is it about?

In this study we showed that zonulin can be considered a diagnostic biomarker in NCGS and combined with demographic and clinical data differentiates NCGS from IBS-D with high accuracy.
Distinguishing NCGS from IBS-D is of greater value in clinical practice, where the clinician is confronted with the dilemma of placing a patient on a gluten-free diet. In addition simplicity and non-invasiveness of the proposed test suggest that zonulin and the related algorithm could be a clinically valid diagnostic biomarker in NCGS.

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