Clinical characteristics and outcomes of patients with end-stage renal disease hospitalized with diabetes ketoacidosis

What is it about?

1. What is already known about this subject? 

There is limited evidence on the management and outcomes of patients with ESRD admitted with DKA. 

2. What are the new findings?

Compared to patients admitted with DKA and preserved renal function, patients with ESRD:
•	presented with higher admission blood glucose, but lower hemoglobin A1c
•	have higher rates of hypoglycemia, volume overload and need for mechanical ventilation 
•	have similar mortality, but longer length-of-stay and higher hospital costs

3. How might these results change the focus of research or clinical practice? 

The poor clinical outcome observed in patients with ESRD highlights the need for close glucose monitoring and a personalized approach to volume replacement during treatment for DKA; as well as the need for prospective studies to assess personalized management algorithms to improve treatment-related complications and reduce healthcare utilization in this high-risk population. 


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