What is it about?
We aimed to explore recent research on the comorbidity of common NDD, including aetiopathogenesis, concepts of diagnosis and implications for management strategies by conducting a systematic review of the literature. Four alternative hypotheses have been published to conceptualise how comorbid NDEBID are classified and understood: (1) Neuroconstructivism, (2) ‘Neurodevelopmental Disability’, (3) ‘Overarching Spectrum of ASD-ADHD disorder’ and (4) ‘Severe Autism Spectrum’ concepts.
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Why is it important?
Neurodevelopmental disorders (NDD) often co-occur in clusters with a wider range of emotional, behavioural, and intellectual disorders. This common scenario has led some authors to introduce the concept of ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) (Gillberg, 2010) and a more unified terminology of NDEBID (Neurodevelopmental, Emotional, Behavioural and Intellectual disorders (Ogundele & Morton, 2022).
Perspectives
Most NDEBID conditions have unknown aetiology and lack circumscribed psychopathology but typically based solely upon description of psychopathology. They often share symptoms and manifestations that are not mutually exclusive to any one discrete condition. Attempts at classifying various NDD has gone through a wide range of complex and sometimes controversial changes over the past five decades, with the WHO’s International Classification of Diseases (ICD) and the American Psychiatric Association’s Diagnostic and Statistical Manual (DSM) emerging as the commonest clinical and research standards.
Dr Michael O Ogundele
Mid Cheshire Hospitals NHS Foundation Trust Postgraduate Medical Centre
Read the Original
This page is a summary of: 6846 Concept of neurodevelopmental comorbidities: do we need a paradigm shift?, July 2024, BMJ,
DOI: 10.1136/archdischild-2024-rcpch.427.
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