Zeolites can be used as a highly selective stationary phase in HPLC

What is it about?

The use of nano-porous materials like metal-organic frameworks (MOF) and covalent organic frameworks (COF) as separation media is a clear trend in separation sciences. However, these materials are not perfect for the use in HPLC due to limited hydrolytic, mechanical and thermal stabilities. Old good inorganic zeolites represent an excellent alternative to MOF and COF, but they are rarely used in HPLC. Probably, this is due to the lack of information on zeolites. This article reviewed all data on the application of zeolites as a stationary phase in HPLC.

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Why is it important?

There are examples of the excellent selectivity achieved with nano-porous materials for very difficult separations of various isomers (geometrical, enantiomers, isotopologues etc.). For example, simple and heavy water can be separated with separation factor of 210! So, there is a strong demand in finding new selective and robust materials for the use in HPLC.

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