What is it about?
A simple, sensitive, precise, accurate, highly reproducible and economical, visible spectrophotometric method for the determination lurasidone in bulk form was developed and validated. The method is based on the formation of an oxidative coupling product by the reaction of lurasidone with 3-methylbenzothiazolin- 2-one hydrazone as a chromogenic reagent in presence of ferric chloride.
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Why is it important?
The linear regression analysis data for the calibration plot showed good linear relationship within the concentration range of 0– 100 μg/mL with a correlation coefficient (r) value of 0.9997.
Perspectives
The limits of detection and quantitation are 0.6 and 1.7 μg/mL, respectively. The method was tested and validated according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (RSD < 2%).
Prof Ratnakaram Venkata Nadh
GITAM University
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This page is a summary of: Oxidative Coupling Reaction for the Determination of Lurasidone, Journal of Analytical Chemistry, June 2019, Pleiades Publishing Ltd,
DOI: 10.1134/s1061934819060121.
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