The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated Genes

What is it about?

STAT2 is a key transcription factor regulating gene expression in response to interferon (IFN) during antiviral responses, but its mechanism of action remains poorly understood. We isolated nuclear proteins interacting with the STAT2 transactivation domain, identifying two putative ATPases, RVB1 and RVB2. These proteins were required for IFN-α-stimulated (STAT2-dependent) gene expression but not for gene expression induced by IFN-γ (STAT1 dependent) or tumor necrosis factor alpha (NF-κB dependent). RVB proteins were required for RNA polymerase but not STAT2 recruitment to target promoters. No known RVB-interacting protein was required, suggesting that STAT2 stimulates transcription through recruitment of as yet unidentified RVB chromatin remodeling complexes.

Featured Image