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The F-box DNA helicase (Fbh1) functions in direct opposition to Rad22 (=Rad52) to curb Rad51 loading onto DNA. This plays a key role in preventing recombination when replication forks are blocked and/or broken. We suggest that Fbh1 exerts its control on recombination by acting as a Rad51 disruptase.
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This page is a summary of: Fbh1 Limits Rad51-Dependent Recombination at Blocked Replication Forks, Molecular and Cellular Biology, June 2009, ASM Journals,
DOI: 10.1128/mcb.00471-09.
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