What is it about?
identification and biochemical characterisation of the proteins that specifically bind or degrade (p)ppGpp
Featured Image
Why is it important?
(p)ppGpp is a universal second messenger in bacteria and essential for bacterial stress biology, tolerant to many stresses including antibiotics insults (or persistence), and virulence gene expression. Identification of the proteins that specifically interact with (p)ppGpp laid the foundation for better understanding of the molecular mechanisms bacteria employ for stress (in particular antibiotics) tolerance.
Perspectives
Further analysis of the identified targets (undergoing now) probably reveal novel aspects of bacterial stress biology that could be exploited to counteract bacterial multidrug tolerance.
YONG ZHANG
Read the Original
This page is a summary of: Novel (p)ppGpp Binding and Metabolizing Proteins of Escherichia coli, mBio, March 2018, ASM Journals,
DOI: 10.1128/mbio.02188-17.
You can read the full text:
Resources
Contributors
The following have contributed to this page
