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Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are specific for HIV-1 and cannot be used in SIV macaque models for HIV/AIDS. This class of drugs is one of the most prescribed in combination antiretroviral therapy. We developed a new chimeric virus in which the reverse transcriptase (RT) coding region of SIV was replaced by HIV-1 RT, called RT-SHIV. This allows us to study NNRTIs alone and in combination with other drugs in SIV macaque models.

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This page is a summary of: In Vitro Characterization of a Simian Immunodeficiency Virus-Human Immunodeficiency Virus (HIV) Chimera Expressing HIV Type 1 Reverse Transcriptase To Study Antiviral Resistance in Pigtail Macaques, Journal of Virology, December 2004, ASM Journals,
DOI: 10.1128/jvi.78.24.13553-13561.2004.
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