N74D HIV-1 capsid mutant has increased dependence on cyclophilin A, cannot replicate in macrophages

What is it about?

The antiviral factor CPSF6-358 interferes with the nuclear entry of human immunodeficiency virus type 1 (HIV-1). HIV-1 acquires resistance to CPSF6-358 through the N74D mutation of the capsid (CA), which alters its nuclear entry pathway. Here we show that compared to wild-type (WT) HIV-1, N74D HIV-1 requires cyclophilin A for replication in cell lines but is dependent on other interactions in macrophages.

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