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A candidate vaginal microbicide, 2-hydroxypropyl-β-cyclodextrin (BCD), protected 90% of rhesus macaques from high-dose intravaginal SIV challenge. However, upon a second exposure of BCD and SIV led to 75% of the same animals becoming infected. Intravaginal SIV exposure in the presence of BCD appeared to sensitize the animals to subsequent infection, reducing the efficacy of the drug.

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This page is a summary of: Incomplete Protection against Simian Immunodeficiency Virus Vaginal Transmission in Rhesus Macaques by a Topical Antiviral Agent Revealed by Repeat Challenges, Journal of Virology, April 2008, ASM Journals,
DOI: 10.1128/jvi.02730-07.
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