What is it about?
Following HIV-1 infection, some people advance rapidly toward AIDS while others have a slow disease progression. HLA-C, a molecule involved in immunity, is a key determinant of HIV-1 control.
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Why is it important?
Here we reveal how HLA-C variants contribute to modulate viral infectivity. HLA-C is present on the cell surface in two different conformations: the immunologically active conformation is part of a complex that includes β2-microglobulin/peptide; the other conformation is not bound to β2-microglobulin/peptide and can associate with HIV-1, increasing its infectivity. Individuals with HLA-C variants with a predominance of immunologically active conformations would display a stronger immunity against HIV-1, a reduced viral infectivity and an effective control of HIV-1 infection, while subjects with HLA-C variants that easily dissociate from β2-microglobulin/peptide would have a reduced immunological response to HIV-1 and produce more infectious virions.
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This page is a summary of: Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity, Journal of Virology, October 2017, ASM Journals,
DOI: 10.1128/jvi.01711-17.
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