What is it about?
Most of what we've known about replication fidelity in RNA viruses come from studies of the viral RNA dependent RNA polymerase. Here, we describe a variant of the nsp2 protease/helicase that also determines replication fidelity, and we show that it better resists the effects of unbalanced intracellular nucleotide concentrations. Our data contribute to a growing body of work indicating that other proteins involved in replication can also determine fidelity and RNA virus mutation rates.
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Why is it important?
Our data contribute to a growing body of work indicating that other proteins involved in replication can also determine fidelity and RNA virus mutation rates.
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This page is a summary of: Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion, Journal of Virology, August 2015, ASM Journals,
DOI: 10.1128/jvi.01553-15.
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