Whole-genome multilocus sequence typing of resistant Gram-negative bacteria

What is it about?

Whole-genome multilocus sequence typing is a new molecular technique to type bacteria. In this paper typing schemes for the most common ESBL-producing Gram-negative bacteria are proposed. In addition, thresholds for genetic distance are proposed that can be used to identify related bacterial isolates in hospital settings.

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Why is it important?

This is the first study proposing wgMLST typing schemes for ESBL-producing bacteria and setting thresholds for genetic distance that are based on a large collection of epidemiologically related and unrelated ESBL-producing isolates.