What is it about?

In this paper, we described that some amino acid residues are involved in conformational changes of the flagellar filament protein, flagellin.

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Why is it important?

It is a unique report describing which part of protein is responsible for changing protein conformation.

Perspectives

Conformational changes of protein, such as flagellar filament transformation, are important for protein function, not only in structure but in activity. This paper is a starting point to define which interactions are important for conformational changes in different conditions of pH, salt concentration, and etc.

Kenji Oosawa
Gunma University

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This page is a summary of: Key Amino Acid Residues Involved in the Transitions of L- to R-Type Protofilaments of the Salmonella Flagellar Filament, Journal of Bacteriology, May 2013, ASM Journals,
DOI: 10.1128/jb.02091-12.
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