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C. glabrata is a commensal of mucosal surfaces, but also a common pathogen and relatively closely related to the baker's yeast S. cerevisiae. We propose that C. glabrata must have evolved specific properties and activities for adaptation to the host. This is another example of such adaptation: in contrast to S. cerevisiae, C. glabrata has adapted to use histidine as a sole source of nitrogen. For process, C. glabrata requires the aromatic amino acid aminotransferase Aro8, but not Aro9

Bernhard Hube

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This page is a summary of: Histidine Degradation via an Aminotransferase Increases the Nutritional Flexibility of Candida glabrata, Eukaryotic Cell, April 2014, ASM Journals,
DOI: 10.1128/ec.00072-14.
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