What is it about?
This theoretical modeling study helps to predict what types of potential novel antibacterial compound should penetrate into bacterial cells.
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Why is it important?
A significant problem in designing new antibiotics is that Gram-negative bacteria pump foreign compounds out of the cell and that the physical measurements of rates of compound influx and efflux are technically difficult. This work increases the understanding of how efflux rates and influx rates interact and it also justifies some simple measurements of the antibacterial activities of compounds that allow inferences to be made about influx and efflux rates. That justification enables those simple measurements to be used with more confidence in antibacterial drug discovery.
Perspectives
It is hoped that sharing this theoretical modeling will stimulate other researchers to test its predictions experimentally which, whatever the outcome, will drive further understanding in the area.
Wright Nichols
Consultant Microbiologist
Read the Original
This page is a summary of: Modeling the Kinetics of the Permeation of Antibacterial Agents into Growing Bacteria and Its Interplay with Efflux, Antimicrobial Agents and Chemotherapy, July 2017, ASM Journals,
DOI: 10.1128/aac.02576-16.
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