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Here, we give insight into the function of SHANK3 besides the central nervous system and imply new potential treatment strategies for SHANK3- autism patients. For the study, we used human stem cell derived muscle/neuron co-culture systems.
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This page is a summary of: Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles, Science Translational Medicine, June 2020, American Association for the Advancement of Science,
DOI: 10.1126/scitranslmed.aaz3267.
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