What is it about?
The drug 5-fluorouracil is a widely used compound for treatment of various types of cancer. Its anticancer activity is increased by the addition of folinic acid, a form of vitamin B9. This combination has proven efficacy and is now currently used for treatment of various types of cancer, notably gastro-intestinal and more recently pancreatic carcinomas. We demonstrate herein that the potency of the 5-fluorouracil combined with folinic acid is augmented by the addition of Pyridoxal 5'-phosphate, a form of vitamin B6. The paper contains the biochemical rationale for this new combination and suggestion that the effect is potentially feasible in vivo.
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Why is it important?
The new combination offers the potential to enhance the efficacy of 5-fluorouracil for treatment of cancer
Perspectives
Further demonstration is required in vivo, through animal tumor models and/or adequate clinical explorations in cancer patients accompanied with dose-finding and pharmacokinetic studies.
David Machover
University Paris-Sud, and INSERM U935, Villejuif, France
Read the Original
This page is a summary of: Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5′-Phosphate and Folinic Acid in Tandem, Journal of Pharmacology and Experimental Therapeutics, June 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/jpet.118.249367.
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