What is it about?
Based on data from 200 patients undergoing sedation with propofol and remifentanil we have developed a mathematical model relating drug concentrations to transcutaneous CO2 levels. Based on this model, predictions can be made about expectations of respiratory depression, a potentially severe side effect, to improve sedation management by avoding dangerous problems.
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Why is it important?
Our model is based in drug and pCO2 levels quantitated noninvasively analyzed using nonlinear mixed effects modeling and allows prediction of a side effect, respiratory depression, in a way that no other previous model allows
Perspectives
It is part of an effort to individualize and improve monitoring systems in the area of sedation where low accuity monitors are used by generating a quantitative approach based on the experience gathered in hundreds of patients undergoing sedation with propofol and remifentanil
Pedro Gambus
Hospital Clinic de Barcelona
Read the Original
This page is a summary of: Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2, Journal of Pharmacology and Experimental Therapeutics, December 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/jpet.115.226977.
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