What is it about?
To benefit the overall wound healing process, we aimed to analyze the usage of pretreated sutures for improving the implantation of MSCs in the tissues.
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Why is it important?
Our results firstly showed that suture pretreatments with gelatin, poly-L-lysine, and NaOH improved the adhesive strength of MSCs to sutures. These cells remained surrounding the sutured tissue and no significant phenotypic changes were found in those cells cultured onto pretreated sutures. In vivo experiments showed that the implantation of MSCs by suturing increases the collagen content in the sutured tissue. Moreover, proteomics analysis of secreted proteins showed that collagen alpha-1(I) chain was the most abundant collagen found.
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This page is a summary of: Mesenchymal stem cell-coated sutures enhance collagen depositions in sutured tissues, Wound Repair and Regeneration, March 2014, Wiley,
DOI: 10.1111/wrr.12153.
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