What is it about?
T cells are essential for inducing an antitumoral immune response, but tumors develop an adverse environment for the T cells, such as low O2 tension (hypoxia). We show for the first time that T cells infiltrating the pleura of lung cancer patients do not increase the expression of the glucose transporter Glut1; in consequence, T cells cannot take up glucose under hypoxia when they are stimulated.
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Why is it important?
Our findings show that even when T cells are properly stimulated, they cannot use glucose for their nutrimental needs in an hypoxic environment. In consequence, T cells cannot exert their antitumoral functions. Thus, lung cancer sabotages the metabolism of the T cells as a tumor evasion mechanism that might favor tumor survival.
Perspectives
This article shows the importance of studying the metabolism of immune cells in lung cancer and it might provides venues for novel treatments.
Heriberto Prado-Garcia
Instituto Nacional de Enfermedades Respiratorias "Ismael Cosio Villegas"
Read the Original
This page is a summary of: Deficient glucose uptake is linked to impaired Glut1 expression upon
CD
3/
CD
28 stimulation in memory T cells from pleural effusions secondary to lung cancer, Scandinavian Journal of Immunology, July 2019, Wiley,
DOI: 10.1111/sji.12802.
You can read the full text:
Resources
CD8+ T cell dysfunction induced by lung carcinomas
This is a set of the articles that we have published concerning the study of defects in cytotoxic T cells from lung cancer patients
Supplemental Figure 1 from the article
Stimulation increase the expression of percentages of transferrin receptor (CD71) in T cells from nonmalignant and lung cancer patients.
Supplemental Figure 2 from the article
CD98 amino acid transporter is upregulated in T cells after stimulation
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