What is it about?
The idea behind this work is to compare the behavior of 2 different lines of Leishmania donovani during the course of the infection inside 2 different lab model, the white mice and in the hamster. For this we selected a strain of L. donovani from Ethiopia and one from Nepal because of their genetic differences. After monitoring different parameters such as parasite count in the liver and the spleen, the number of recruited immune cells and the level of different immuno-modulatory molecules we concluded that the strain from Nepal was less infective than the strain from Ethiopia and elicits less the immune system.
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Why is it important?
The lines of parasites we compared are used in many studies. It is very important to know how we can translate the finding from on to another. Up to the publication of this work, nobody compared parasite lines of L. donovani from the 2 main endemic regions for VL on Earth.
Perspectives
This first study shows interesting results but in order to draw a broader conclusion on the genetic and on the geographical distance we need to include more lines from those 2 regions.
Dr Franck Dumetz
University of Maryland
Read the Original
This page is a summary of: In vivocharacterization of two additionalLeishmania donovanistrains using the murine and hamster model, Parasite Immunology, April 2016, Wiley,
DOI: 10.1111/pim.12316.
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