What is it about?
Photodynamic therapy (PDT) is a treatment that can selectively kill cells and tissues using a photosensitizer activated by specific light. It's advantageous because it targets diseased tissues while sparing normal ones. PDT is explored for treating metastatic melanomas due to its noninvasiveness and low side effects. Traditional red or blue light sources are used to activate photosensitizers for skin cancer therapy. A suitable photosensitizer should be a pure compound, stable, cost-effective, and produce a lot of reactive oxygen species when exposed to specific light. The efficiency of singlet oxygen production is crucial. The photosensitizer should be non-toxic in the dark and quickly clear from normal tissues to minimize side effects. In this study, a green fluorescent pyrene-based photosensitizer called TPPy showed promise for PDT. It was effective against melanoma cells in vitro and displayed no toxicity in vivo using a Galleria mellonella model.
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Why is it important?
TPPy demonstrated potential for topical use in skin cancer treatment.
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This page is a summary of: In vitro Studies of Antitumor Effect, Toxicity/Cytotoxicity and Skin Permeation/Retention of a Green Fluorescence Pyrene‐based Dye for PDT Application, Photochemistry and Photobiology, October 2020, Wiley,
DOI: 10.1111/php.13335.
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