What is it about?
The aim of this study was to test whether prediction of childhood asthma by genetic determinants varies with the environmental setting, particularly the farm exposure. Asthma is known to occur partly due to a genetic predisposition and partly due to environmental exposures. However, it is also established that some environments protect against the occurence of asthma, such a exposure to farming environments (https://link.growkudos.com/1b2ppqfmm0w).
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Why is it important?
Improving genetic prediction of asthma can help to identify subjects at risk early in life so that preventive measures can be taken. The strong evidence for interaction between genetic predisposition and environmental exposure in asthma development necessitates environment-specific genetic prediction models. This study defines genetic prediction specific to very distinct environmental exposures in childhood, farming and non-farming environments, which are already established at birth and unlikely to change substantially throughout early childhood.
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This page is a summary of: Asthma in farm children is more determined by genetic polymorphisms and in non‐farm children by environmental factors, Pediatric Allergy and Immunology, September 2020, Wiley,
DOI: 10.1111/pai.13385.
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