What is it about?
Longitudinal urinary metabolomics analysis in this study identifies four metabolites significantly associated with early childhood asthma. Identified asthma-associated metabolites are shown in blue color. Among them, 1-methylnicotinamide, a primary metabolite of nicotinamide, is reported to be protective against asthma exacerbations through anti-inflammatory effects. Another three metabolites are originated from choline and purine metabolisms. Guanidoacetic acid is a natural precursor of creatine which has been reported to activate airway epithelium in asthma. Most importantly, dimethylamine (DMA) and allantoin are responsible for gut microbial metabolism in diverse environments.
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Why is it important?
Metabolic pathway analysis of longitudinal urinary metabolomic profiling provides a link of microbe-environment interactions in the development of childhood asthma.
Perspectives
Longitudinal urinary metabolomic profiling provides a link of microbe-environment interactions in the development of childhood asthma, suggesting that an alteration of metabolic switching, through dietary or other environmental influences, may represent an opportunity to reduce the prevalence of childhood asthma.
Chih-Yung Chiu
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This page is a summary of: Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood, Pediatric Allergy and Immunology, June 2018, Wiley,
DOI: 10.1111/pai.12909.
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