SCFSNIPER7 controls protein turnover of unfoldase CDC48A to promote plant immunity

What is it about?

The unfoldase CDC48 (Cell Division Cycle 48) is highly conserved in eukaryotes, serving to extract ubiquitinated proteins from large protein complexes and membranes. Although its biochemical properties have been extensively studied in yeast and animal systems, the biological roles and regulations of plant CDC48s were only recently explored. Here we describe the identification of a novel E3 ligase SCFSNIPER7 from the SNIPER (snc1-influencing plant E3 ligase reverse genetic) screen, which contributes to plant immunity regulation by targeting CDC48 for degradation. Taken together, this study reveals a new mechanism of regulating unfoldase levels for controlling immune output.

Featured Image