What is it about?
Gentamicin (GM) is one of the commonest causes of drug-induced nephrotoxicity. Moreover, oxidative stress plays an important role in gentamicin-induced nephrotoxicity. The current study aimed to explore the antioxidant and protective effects of Pimpinella anisum (P. anisum) on the alleviation of GM-induced damage.
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Why is it important?
We demonstrated the potential therapeutic impact of P. anisum to attenuate GM-induced nephrotoxicity. Therefore, the simultaneous use of ethanolic extract of P. anisum during GM administration is recommended to reduce its nephrotoxicity effects.
Perspectives
Gentamicin (GM)-induced nephrotoxicity significantly increases the level of creatinine, blood urea nitrogen (BUN) and reactive oxygen species (ROS). Ethanolic pimpinella anisum extract, due to its multiple active ingredients with antioxidant and anti-inflammatory properties, prevents the emergence of oxidative stress and can be effective in alleviating GM-induced nephrotoxicity in rats.
Reza Nedaeinia
Student Research Committee, Department of medical biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Read the Original
This page is a summary of: Pimpinella anisum L.ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats, Nephrology, January 2017, Wiley,
DOI: 10.1111/nep.12953.
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