Anatomy of spaces around blood vessels in cerebral amyloid angiopathy

What is it about?

Cerebral white matter hyperintensities are the most frequent brain imaging finding in patients with small vessel disease or dementia. Dilated spaces around blood vessels in the brain are related to the failure of intramural periarterial drainage of ISF and solutes along arterial basement membranes. This paper describes the exact anatomical location of dilated spaces in the brain of a dementia patient using transmission electron microscopy.

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Why is it important?

Based on our observations we propose a mechanism by which intramural periarterial drainage of ISF and solutes becomes compromised causing dilated spaces around blood vessels in the elderly and sufferers of dementia.