The Rgg1518 transcriptional regulator is a necessary facet of sugar metabolism and virulence in Streptococcus pneumoniae

What is it about?

Streptococcus pneumoniae is an important cause of serious diseases. The ability of the microbe to sense and respond to environmental stimuli as a community is believed to be an important facet of its survival and virulence. Here we studied a quorum-sensing system called Rgg1518/Shp158. We showed that this system is important for pneumococcal mannose and galactose metabolism, controls capsule biosynthesis and plays an important role in pneumococcal colonization and virulence.

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