Glucose availability dictates the export of the soluble and prion forms of Sup35p via periplasmic or extracellular vesicles

What is it about?

We previously showed that infectious Sup35p prion particles are exported outside the cells via extracellular vesicles (EV). Here we report a significant export of Sup35p within periplasmic vesicles (PV) upon glucose starvation. PV and EV are different in terms of abundance, size and protein content, and their export is oppositely regulated by glucose availability in the growth medium.

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