Iron deficiency leads to repression of a non‐canonical methionine salvage pathway in Schizosaccharomyces pombe

What is it about?

The methionine salvage pathway is initiated by 5-methylthioadenosine and consists of six enzymatic reactions that serve to regenerate methionine. Under low iron conditions, The Adi1 and Mug14 proteins are negatively regulated by Php4 in vegetative cells and cells undergoing meiotic division, respectively. Furthermore, the iron-dependent methionine salvage pathway includes a non-canonical third enzymatic step that requires two functionally interdependent proteins during mitosis (Mta3 and Mde1) and meiosis (Mta3 and Mug14).

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