The UDP‐GalNAcA biosynthesis genes gna ‐ gne2 are required to maintain cell envelope integrity and in vivo fitness in multi‐drug resistant Acinetobacter baumannii

What is it about?

Despite its clinical importance (multi-drug resistance and high mortality rate), the factors contributing to the pathogenesis of Acinetobacter baumannii are not well characterized. Herein, we characterized the contribution of the UDP-<i>N</i>-acetyl-D-galactosaminuronic acid (UDP-GalNAcA) biosynthesis genes tviBC in the pathobiology of A. baumannii. We showed that in addition to their importance for capsule production, <i>gna</i>-<i>gne2</i> are also required to maintain the cell envelope integrity, influence antibiotic resistance, and are essential during bloodstream infection.

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